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KMID : 1098419990070040263
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Korean Journal of Medicinal Crop Science
1999 Volume.7 No. 4 p.263 ~ p.268
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Comparison of Hepatic Detoxification activity and reducing Serum Alcohol concentration of Hovenia dulsis THUNB and Alnus japonica Steud.
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An Sang-Wook
Kim Young-Gil
Kim Min-Hae
Lee Byung-Ik
Lee Sang-Ho
Kwon Hyuk-Il
Hwang Baik
Lee Hyeon-Yong
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Abstract
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It was found that the level of alcohol concentration in both mouse and human sera can be significantly decreased up to 42% by oral administration of the mixtures of the extracts of Hovenia dulcis THUNB and Alnus japonica Steud. A single treatment of extract from Hovenia dulcis reduced the serum alcohol concentration to 32% compared to 13% in treating the extract of Alnus japonica. Similar patterns were observed in enhancing alcohol dehydrogenase (ADH) and glutathion-S-transferase (GST) activity in the liver. The inhibition of cathepsin activity was also greatly reduced by administrating the mixture of both extracts : however, the extract of Alnus japonica did not affect the acitivity of cathepsin. It was concluded that the mixture of both extracts had synergic effect on reducing serum alcohol concentration and improving the detoxification process due to alcohol administration in the liver.
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KEYWORD
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Serum alcohol concentration, Hovenia dulcisTHUNB, Alnus japonica, liver detoxification
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